Isradipin
Category
Isradipin Brand names, Isradipin Analogs
Isradipin Brand Names Mixture
No information avaliable
Isradipin Chemical_Formula
C19H21N3O5
Isradipin RX_link
http://www.rxlist.com/cgi/generic2/israd.htm
Isradipin fda sheet
Isradipin msds (material safety sheet)
Isradipin Synthesis Reference
P. Neumann, U.S. Pat. 4,466,972 (1984)
Isradipin Molecular Weight
371.387 g/mol
Isradipin Melting Point
168-170 oC
Isradipin H2O Solubility
Practically insoluble (< 10 mg/L at 37 °C)
Isradipin State
Solid
Isradipin LogP
2.901
Isradipin Dosage Forms
Capsules (2.5 mg or 5 mg)
Isradipin Indication
For the management of hypertension. It may be used alone or concurrently with thiazide-type diuretics.
Isradipin Pharmacology
Isradipine, the most potent calcium-channel blocking agent of the dihydropyridine class, is similar to nifedipine, amlodipine, and felodipine. It binds to calcium channels with high affinity and specificity and inhibits calcium flux into cardiac and smooth muscle. The effects observed in mechanistic experiments in vitro and studied in intact animals and man are compatible with this mechanism of action and are typical of the class.
Isradipin Absorption
Isradipine is 90%-95% absorbed and is subject to extensive first-pass metabolism, resulting in a bioavailability of about 15%-24%.
Isradipin Toxicity
Symptoms of overdose include lethargy, sinus tachycardia, and transient hypotension. Significant lethality was observed in mice given oral doses of over 200 mg/kg and rabbits given about 50 mg/kg of isradipine. Rats tolerated doses of over 2000 mg/kg without effects on survival.
Isradipin Patient Information
Description
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For those patients who have high blood pressure, and is sometime used to treat angina
(chest pains).
General Information
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This information is for educational purposes only. Not every known side effect, adverse
effect, or drug interaction is in this database. If you have questions about your medicines,
talk to your healthcare provider.
Proper use of this medicine
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Take this medicine exactly as directed. This medicine is normally taken once daily. It is
taken orally and may be taken with or without food. The extended-release tablet and capsule
should be swallowed whole. Do not chew, divide, or crush the extended-release tablet or
capsule.
Missed Dose
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Take your next dose as soon as you remember. If it is time for your next dose, skip the
missed dose and go back to your regular schedule. Do not double doses.
Storage
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Keep this medication in the container it came in, tightly closed, and out of reach of
children. Store it at room temperature and away from excess heat and moisture. Throw away
any medication that is outdated or no longer needed.
Possible Side Effects
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If you experience other bothersome side effects, contact your health care provider.
Some common side effects reported with this medicine include:
nausea
dizziness
headache
swelling
Warnings/Precautions
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Do not stop suddenly stop this medicine without talking to your doctor.
This medicine can cause dizziness. Use caution when operating a motor vehicle.
Overdose
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Seek medical attention immediately. For non emergencies, contact your local or regional
poison control center
Drug Interactions
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Tell your doctor and pharmacist about all other medicines that you are taking, including
non-prescription medicines, nutritional supplements, or herbal products.
Pregnancy/Nursing
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If you suspect that you may be pregnant, talk to your doctor. There are no clear answers,
but animal studies suggest caution during pregnancy, and use should only be when risks are
outweighed by possible benefits. For nursing mothers, it is not known if amlodipine is
excreted in breast milk, so caution is recommended.
More Information
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For more information about this medicine, talk to your healthcare provider.
Isradipin Organisms Affected
Humans and other mammals
